SLC25A37 and neoplasm: Of note, in a subsequent experiment where we harvested tumors shortly after MFRN2 targeting, we observed that combined MFRN1/2 perturbation was associated with apoptosis, specifically an increased expression of cleaved caspase (Fig. 6c), as well as an increase in DNA-damage markers in tumor tissues (Fig. 6d) thereby corroborating our in vitro results and providing a mechanistic explanation for its marked impact on tumor growth.