Similarly, in breast cancer, the overexpression of prostate tumor overexpressed-1 has been found to inhibit DKK1 transcription through the recruitment of histone deacetylase 1(HDAC1) and HDAC2, resulting in decreased levels of histone H3/H4 acetylation at the DKK1 promoter [109]. This evidence concerns the gene DKK1 and breast cancer.