Interestingly, the phenotype of these adult, surviving HRAS/NRASDKO mice shares common features with previously reported mouse RASopathy models, including (i) cranial, lung and heart abnormalities, (ii) hematologic disorders, thrombocytopenia and increased bleeding times, and (iii) increased intracellular levels of KRAS-GTP and activated pERK. The gene discussed is KRAS; the disease is RASopathy.