EIF2AK3 and Noonan syndrome: In this report, we observed that, in addition to a sizeable reduction of body weight, the HRAS/NRASDKO adult mice displayed also various craniofacial defects, involving a reduced cranial vault length and the presence of cranial suture closure abnormalities, which could probably be mechanistically linked to increased pERK signaling as previously described in a mouse model of Noonan syndrome [28].