PTBP1 and osteoarthritis: For example, the lncRNA AC006064.4-201 is downregulated in aging and degenerated human cartilage and can destroy the stability of cyclin dependent kinase inhibitor 1B (CDKN1B) mRNA through interaction with polypyrimidine tract binding protein 1 (PTBP1), alleviate cartilage aging and prevent osteoarthritis [30].