TGFB1 and colon carcinoma: Moreover, the data obtained from RNAseq analyses performed on SARS-CoV-2-infected Caco-2 cells (i.e., derived from a colon carcinoma) treated with Solution-3 also show modulation of signaling cascades responsible for immunosuppressive mechanisms within the tumor microenvironment (e.g., PI3K-Akt and TGF-β, as shown in Fig. 4D, and listed in Additional file 9).