Among them, the complement and coagulation cascades (involving genes C3, PROC, SERPIND1), and the mitogen activated protein kinases (MAPK) pathway (involving genes FLNB, CACNA1D, TAOK2, CACNB1, FLT4, NR4A) were associated with CVT. The gene discussed is CACNA1D; the disease is congenital vertical talus.