ALF transcription elongation factor 3 (AFF3), also known as MLLT2-like, LAF4, and KINS, belonged to the AF4/FMR2 family and encoded a nuclear protein involving multiple biological processes, including autoimmune diseases, tumorigenesis, intellectual disability, horseshoe kidney, and so on [33–35]. The gene discussed is AFF2; the disease is urogenital neoplasm.