Although no SNP reached the genome-wide significance, we identified WWTR1, EXT1, INTU, MAP3K7CL, MAMDC2, BZW1/CLK1, LINC01197, LINC01894, and CFAP95 (C9orf135) as prominent COPD susceptibility loci found in Taiwan. Here, MAMDC2 is linked to chronic obstructive pulmonary disease.