SLC12A5 and neoplasm: Following EZH2 overexpression, significant changes were observed in the mRNA levels of SYNPR and SLC12A5. One of the crucial mechanisms by which EZH2 promotes tumor progression is as a catalytic subunit of the PRC2 complex, which silences tumor suppressor gene transcription by forming H3K27me3 (Margueron and Reinberg 2011).