Multivariate Cox regression showed that age (HR = 2.938, 95%CI = 1.326–7.707), BNP (HR = 3.608, 95%CI = 1.505–9.119) and miR-320a-3p (HR = 2.763, 95%CI = 1.089–7.031) were independent prognostic factors for 48-month survival in CHF patients (Table 2, P < 0.05). This evidence concerns the gene NPPB and congestive heart failure.