The HCT116 colorectal carcinoma cells were engineered with auxin-inducible degron (mAID) tags on NSMCE4A and SMC6 subunits for inducible depletion of SMC5/6 upon treatment with indole-3-aceticacid (IAA) as previously described (Appendix Fig. S2f) (Natsume et al, 2016; Venegas et al, 2020). This evidence concerns the gene SMC6 and colorectal carcinoma.