Of particular interest, the intronic SNP rs186892211 in the ADGRL2 locus (Appendix Fig. S10A) is associated with large-artery atherosclerosis and subsequent ischemic stroke (TOAST classification) with a very high odds ratio (odds ratio 720; P < 3.134e-10, Appendix Fig. S10B). The gene discussed is ADGRL2; the disease is ischemic stroke.