We then performed the Histological examination of tumor tissue sections using hematoxylin and eosin (H&E) staining, confirmed that the RSL3 treatment induced significant cell death in shRNA control U87MG tumors, but the ferroptosis activator did not significantly adversely affect Par-4 knockdown U87MG tumors (Fig. 6i). The gene discussed is PAWR; the disease is neoplasm.