Pre-treatment with ROS scavengers N-acetylcysteine (NAC) and Trolox (6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid) attenuated RSL3-induced Par-4 induction (Fig. 5e), LC3-II conversion, and p62/SQSTM1, FTH1, and NCOA4 degradation in glioma cells (Fig. 5f–h). Here, PAWR is linked to central nervous system cancer.