Through ECM–receptor interaction, Focal adhesion, Human papillomavirus infection, PI3K-Akt signalling pathway, Toll-like receptor signalling pathway signalling pathway, they may play important roles in the course and disease outcome of type 2 diabetes mellitus combined with MASLD, and the results of this study provide meaningful clues and directions for clinical prognosis and treatment. This evidence concerns the gene AKT1 and human papilloma virus infection.