Meanwhile, we also found that in the KEGG enrichment analysis, the two target genes, SPP1 and collagen IV, were mainly involved in the ECM–receptor interaction, Focal adhesion, Human papillomavirus infection, PI3K-Akt signaling pathway, Toll-Akt signaling pathway, and Toll-mediated protein expression. The gene discussed is SPP1; the disease is human papilloma virus infection.