This study showed that the expression of SPP1 was higher in tumour tissues of patients with HCC hepatocellular carcinoma than in paracancerous tissues, and was elevated in patients with advanced BCLC (Barcelona Clinic Liver Cancer) stage, large tumour diameters, and multiple tumour foci in the liver, and was an independent prognostic factor in patients with hepatocellular carcinoma. This evidence concerns the gene SPP1 and liver cancer.