Through ECM–receptor interaction, Focal adhesion, Human papillomavirus infection, PI3K-Akt signalling pathway, Toll-like receptor signalling pathway signalling pathway, they may play important roles in the course and disease outcome of type 2 diabetes mellitus combined with MASLD, and the results of this study provide meaningful clues and directions for clinical prognosis and treatment. The gene discussed is AKT1; the disease is diabetes mellitus.