67 Similarly, EN2 is upregulated in esophageal squamous cell carcinomas68.The genes that have no apparent relationship with esophageal squamous cell carcinomas include BARHL2, HLX, DLX6, DRGX, HMX3, GSX1, IRX3, ARX, and RHOXF1. The gene discussed is RHOXF1; the disease is esophageal squamous cell carcinoma.