In addition, gain-of-function STING mutations have been identified in patients with monogenic autoinflammatory disease and type I interferonopathies, so-called STING-associated vasculopathy with onset in infancy (SAVI)13–17, inflammatory lupus-like disease and familial chilblain lupus18,19. The gene discussed is STING1; the disease is STING-associated vasculopathy with onset in infancy.