Conversely, p27 depletion in the highly metastatic 1833 breast and UMUC3-LuL2 bladder cancer models (Fig. S1d top and bottom, respectively) significantly reduces ES-TFs expression (Fig. 1d left, S1e) and tumor sphere abundance (Fig. 1d right, S1f). This evidence concerns the gene CDKN1B and urinary bladder carcinoma.