The KEGG and GO pathway enrichment analysis revealed that many of the aging-associated pathways were the direct targets of Bcl11b, including the energy/nutrient sensing pathways ‘PI3K-Akt signaling’, ‘mTOR signaling’, ‘AMPK signaling’, which have been implicated in longevity regulation72; the inflammation pathway ‘TNF signaling’; the fate determination pathway ‘Notch signaling”, and ‘Wnt signaling’ and cancer-related pathways (Fig. 6c, d; Supplementary Data 5). The gene discussed is TNF; the disease is cancer.