Interestingly, compared to the adjacent normal tissue, breast tumors were significantly elevated for various senescence related pathways, and the l-Sen program related pathways, including Notch signaling, Wnt signaling (TCF7L1, LEF1), Hedgehog signaling (GLI1, GLI2), and pluripotency related factors (MYC, SOX2 and KLF4), while e-Sen specific NFkB pathway was tuned down (Fig. 3b and Supplementary Fig. 4a-c). This evidence concerns the gene KLF4 and breast neoplasm.