In conclusion, this study is the first to propose a TCC treatment strategy, provide evidence that the TCC therapy was associated with a better prognosis in the clinical treatment of patients with advanced HCC than other treatments, which exert an efficient anti-HCC effect by inducing the SAMD4B-APOA2 axis to inhibit tumour immune evasion. Here, SAMD4B is linked to hepatocellular carcinoma.