TP53 and tarsal-carpal coalition syndrome: Gene enrichment analysis based on the differentially expressed genes among the 6 groups was carried out; notably, in the TCC group, tumour-related signalling pathways were upregulated, including the ErbB, Notch, p53, and MAPK signalling pathways, cell cycle, nucleotide excision repair, and cell adhesion molecules (CAMs) (Fig. 2g).