TRPV1 and cancer: To seek the potential molecular that could sensitize cancer-associated nociceptive nerve endings, we established an OSCC orthotopic xenograft in mice which could induce prominent nociceptive phenotypes.4 Notably, we detected a significantly higher amount of adenosine in TRPV1-positive neuron innervated OSCC xenograft, compared with normal epithelium (Fig. 1c and Supplementary Fig. 1a).