In our study, we first screened differentially expressed genes related to iron death in the multiple sclerosis dataset, including ATM, GSK3B, HMGCR, KLF2, MAPK1, NFE2L1, NRAS, PCBP1, PIK3CA, RPL8, and VDAC3, among others. This evidence concerns the gene MAPK1 and multiple sclerosis.