In our study, we first screened differentially expressed genes related to iron death in the multiple sclerosis dataset, including ATM, GSK3B, HMGCR, KLF2, MAPK1, NFE2L1, NRAS, PCBP1, PIK3CA, RPL8, and VDAC3, among others. The gene discussed is HMGCR; the disease is multiple sclerosis.