We also conducted KEGG enrichment analysis of FRDEGs, which revealed that these genes were primarily enriched in pathways such as cellular senescence, endometrial cancer, FoxO signaling pathway, prolactin signaling pathway, ErbB signaling pathway, B cell receptor signaling pathway, apoptosis, PI3K-Akt signaling pathway, and ferroptosis (Fig. 5B). This evidence concerns the gene PIK3CA and endometrial cancer.