The use of evolocumab, a PCSK9 inhibitor, reduced DRP-1 phosphorylation and the severity of mitochondrial autophagy, suggesting that PCSK9 and DRP-1 are involved in the regulation of mitochondrial autophagy in cardiomyocytes and in the development and progression of HF [91]. The gene discussed is DNM1L; the disease is hydrops fetalis.