Furthermore, a study using intracoronary ultrasound—the Atherosclerosis-Intravascular Ultrasound Study (ATHEROMO-IVUS) showed that high plasma PCSK9 concentrations positively correlate with necrotic core fraction and volume, and this correlation is independent of statin use and plasma LDLc concentration [118]. The gene discussed is PCSK9; the disease is atherosclerosis.