A previous study shown that in patients with a PSA < 10 ng/mL, the median NPV of MRI for overall PCa was 86.3% (IQR, 73.3%–93.6%), with a median cancer prevalence of 35.4% (IQR, 27.6–42.5%) [35]; this was similar to our research results. This evidence concerns the gene KLK3 and cancer.