Compared with ANCA-negative vasculitis cases, the adjusted odds of participants having kidney involvement were 7.8 (95% CI 3.4 to 18.5, p<0.001) and 3.3 (95% CI 1.6 to 6.6, p<0.001) times higher in individuals with MPO-ANCA and PR3-ANCA, respectively. This evidence concerns the gene PRTN3 and vasculitis.