To test if chronic inhibition of PVHSH2B1 neurons causes obesity, Sh2b1‐Cre mice were bilaterally microinjected into the PVH with Cre‐dependent AAV9‐hSyn‐DIO‐Tetanus toxin (Tettox) or AAV9‐hSyn‐DIO‐mCherry (control) vector (Figure S6A, Supporting Information). Here, SH2B1 is linked to Obesity.