SH2B1 and obesity due to melanocortin 4 receptor deficiency: To test if chronic inhibition of PVHSH2B1 neurons causes obesity, Sh2b1‐Cre mice were bilaterally microinjected into the PVH with Cre‐dependent AAV9‐hSyn‐DIO‐Tetanus toxin (Tettox) or AAV9‐hSyn‐DIO‐mCherry (control) vector (Figure S6A, Supporting Information).