PRKAA2 and cancer: Lastly, our data are in line with recent observations, demonstrating that cancer cells with high AMPK activity are resistant to ferroptosis induction.[63] Restraining the biosynthesis of polyunsaturated fatty acids (PUFA) by AMPK‐mediated ACC phosphorylation limits ferroptosis,[63] which is a cell death that is dependent on lipid peroxidation and the abundance of PUFA.[64]