Specifically, BPN 2 has been established with the following features: 1) well‐defined composition and molecular structure; 2) its photoactivity can undergo a dramatic transition from completely inhibited state to highly activated upon triggered by NTR; 3) tumor‐specific background‐free fluorescence/photoacoustic (PA) imaging; 4) ability to produce oxygen‐independent I‐PDT effect and PA cavitation in the target tumor under single‐pulse laser irradiation. The gene discussed is NTSR1; the disease is neoplasm.