We confirmed differential expression of chemoattractant cytokines including Cxcl2 and Cxcl3 in addition to increased expression of pro-inflammatory cytokines including TNF-α and immune regulatory cytokines like TGF-β1, IL-4 and IL-15 in our CALR dependent MPN model. The gene discussed is IL4; the disease is myeloproliferative neoplasm.