Three members, IKZF1 (IKAROS) (rs2366293-C, rs4917014-T), IKZF3 (AIOLOS) (rs2941509-T), and IKZF2 (HELIOS) (rs6435760-C) have been implicated in systemic lupus erythematosus (SLE) (6, 7). The gene discussed is IKZF2; the disease is systemic lupus erythematosus.