Accumulating evidence demonstrates that prognostic biomarkers after cardiac arrest have been widely researched in recent years, including neuron specific enolase (NSE), S-100B, neurofilament light (NfL), ubiquitin carboxy-terminal hydrolase L1 (UHC-L1), glial fibrillary acidic protein (GFAP) and tau protein [47]. The gene discussed is S100B; the disease is cardiac arrest.