Given that this pathway was key to successful anti-tumor immunity and is a feature of M1 macrophages [36], the lower expression of MHC-II and costimulatory factors, as well as loss of antigen presentation function, in TAM was consistent with the more M2-like macrophages in KPP group and the proposed immunosuppressive role of PLK1. This evidence concerns the gene PLK1 and neoplasm.