In conclusion, in this paper, we found for the first time that NGR1 can regulate RUNX2 to affect the AGE-ARCE signaling pathway to inhibit the proliferation of breast cells, and our biggest innovation is that we found that NGR1 induces ferroptosis in breast cancer cells, although our results are encouraging, our experiments still have some limitations, and we only carried out cellular experiments in vitro, and we have not yet carried out in vivo animal experiments to further validate our conclusions. This evidence concerns the gene RUNX2 and breast cancer.