Herein, activation of the TLR4/NF-κB axis in LPS-stimulated RAW 264.7 macrophages was sharply repressed by Rosuvastatin, implying that the suppressed NF-κB signaling might be responsible for the inhibition by Rosuvastatin on the activity of macrophages during sepsis. The gene discussed is NFKB1; the disease is Sepsis.