Insulin resistance, the associated increase in insulin, hyperglycemia, and the disturbed metabolism of adipocyte cytokines may also lead to vascular endothelial dysfunction, abnormal lipid profile, and vascular inflammation, all of which predispose the individual to the development of cardiovascular diseases and/or the metabolic syndrome, the deadly quartet, or the obesity dyslipidemia syndrome. This evidence concerns the gene INS and metabolic syndrome.