GPR158 and major depressive disorder: Since the NAc is a pivotal node in the limbic basal ganglia loop, and its dysfunction results in psychiatric diseases including stress-related disorders such as depression and anxiety (Francis & Lobo, 2017; Gunaydin & Kreitzer, 2016), it is tempting to speculate that Glycine/GPR158-dependent enhancement of MSN excitability we observed could conceivably represent a mechanism by which elevated extracellular glycine levels may promote stress-dependent decisional strategies.