Another likely explanation of the worsening in lipid profile (TG and TC) by TAM + HFD is the inhibition of Peroxisome proliferator-activated receptor-alpha (PPAR-α) which has a pivotal function in elevating LDL and lowering HDL levels contributing to NASH aggravation (Contreras et al. 2013). The gene discussed is PPARA; the disease is metabolic dysfunction-associated steatohepatitis.