Immature, structurally disordered SOD1 conformers have also been found to mislocalize and accumulate in spinal cord motor neurons of SOD1-linked and non-SOD1-linked ALS cases, including sALS and C9ORF72 fALS in a manner specific to regions of neurodegeneration [63]. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.