An important role of miR‐146a and miR‐27a has been observed in patients with ASVCD combined with SARS‐CoV‐2 infection, however, it is unclear whether the regulatory roles of miR‐146a and miR‐27a in ASVCD are affected by SARS‐CoV‐2 infection, therefore, we further obtained PBMCs from 9 follow up ASCVD patients and controls after 1 year of SARS‐CoV‐2 infection, we examined the alterations in the expression of miR‐146a, miR‐27a, and IL‐6 following SARS‐CoV‐2 S protein RBD stimulation in vitro. The gene discussed is IL6; the disease is severe acute respiratory syndrome.