Regarding patient safety outcome variables, the low TTR group was associated with a higher risk of severe infection at both 1 and 6 years and also higher mortality at 6 years (Supplementary Table S11, Supplemental Digital Content 1, http://links.lww.com/JS9/C773 and Supplementary S12, Supplemental Digital Content 1, http://links.lww.com/JS9/C773). The gene discussed is TTR; the disease is infection.