TGF‐β1 is a key mediator in the development of fibrosis and inflammation and plays critical roles in epithelial‐mesenchymal transition (EMT) and fibrosis formation.[6, 10] As expected, PFD@Gel treatment downregulated TGF‐β1 protein expression in tumor tissues, which is consistent with previous reports that PFD induces collagen depletion mainly by suppressing TGF‐β1‐related signaling pathways (Figure S12, Supporting Information). This evidence concerns the gene TGFB1 and neoplasm.