Conversely, immune‐negative cells, such as Tregs (CD4+CD25+Foxp3+) and M2‐TAMs (CD206hiCD11b+F4/80+), were significantly reduced in the groups containing Sfn and siIDO1, especially in the CISE‐PFD@Gel group, suggesting that PFD‐mediated TPME remodeling may contribute to attenuating the postoperative immune suppression status in ccRCC (Figure 7F; Figure S25, Supporting Information). Here, FOXP3 is linked to nonpapillary renal cell carcinoma.