HMGB1 and neoplasm: Sfn, as a molecular targeted anti‐tumor agent, not only directly destroys tumor cells but also activates the body's adaptive immune response by inducing immunogenic cell death (ICD)‐triggered immunogenicity.[41] Therefore, the ICD‐induction capacity of CISE NPs was analyzed in Renca cells by estimating damage‐associated molecular patterns including calreticulin (CRT), high‐mobility group box 1 (HMGB1), and adenosine 5′‐triphosphate (ATP).