FABP4 is a well‐known inflammatory regulator involved in various inflammatory diseases[29] such as ischemic stroke,[49, 50] non‐alcoholic steatohepatitis,[51, 52] and atherosclerosis[53, 54] by activating the JNK, NF‐κB, and JAK2/STAT2 signaling pathways in macrophages. Here, MAPK8 is linked to ischemic stroke.