CD69 and type 1 diabetes mellitus: Nevertheless, the defective immunosuppressive effect in Treg cells was evidenced in both T1D patients and NOD mouse models.[66, 67] In this case, although the usage of anti‐CD69 antibody to deplete TRM cells was accompanied by the potential elimination of CD69+ Treg cells, the beneficial effect of CD69 neutralization in T1D is mainly attributed to TRM cell depletion.