CD274 and neoplasm: It has been suggested that anti-drugs and PD-1/PD-L1 inhibitors can jointly act on the tumor microenvironment, reshaping the tumor vascular and immune microenvironments, transforming the immunosuppressive state into the immune-promoting state, increasing the invasion of T cells to the tumor, and playing a synergistic anti-tumor effect (1 + 1>2) (34, 35).