ACE and Infertility: The absence of ACE isozymes leads to abnormalities in the transportation of sperm in the oviducts and affects its ability to bind to zona pellucida.[68] Deletion polymorphism in the ACE gene in infertile men showed higher oxidative stress which is predicted to have a vital role in the pathogenesis of male fertility by its pro‐oxidative effect and is associated with atypical seminal variables.[67] Proband DIS‐15 is homozygous for the missense variant p.[Arg971Gln] and his semen analysis revealed reduced sperm concentration (oligozoospermia).