The repeat motifs R1 and R2 in exon 7 of TRIOBP‐5 are vital for the actin‐binding.[23] Most of the pathogenic variants reported are localized in exon 7 and affect isoforms TRIOBP‐5 and TRIOBP‐4.[21, 24, 25, 26, 27, 28, 29] Although TRIOBP gene variants are not a common cause for HL, exon 7 may be considered a hotspot region for future genetic screening of HL. The gene discussed is TRIOBP; the disease is Hodgkins lymphoma.