LRGUK and Reduced sperm motility: Variants in Lrguk‐1 in mice lead to reduced sperm concentration along with defects in sperm motility and morphology.[59] Semen analysis of the proband and his brother in the DIS‐2 family indicated reduced sperm concentration (oligozoospermia) and motility (asthenozoospermia), suggesting the homozygous variant p.[Gly297Val] disrupted LRGUK protein function.