BACE1 and Alzheimer disease: For example, miR-16, miR-338-5p, miR-485-5p, miR-107, and miR-186 play a critical role in controlling BACE-1 expression, which affects Aβ production in AD (Maoz et al., 2017; Zhao et al., 2017; Wang et al., 2019; Kou et al., 2020).