The most compelling rationale for progressing anti-CD19 CAR T cell therapy in autoimmune disease came from recently published data in 15 patients with treatment refractory, moderate to severe, SLE, SSc, and idiopathic inflammatory myositis (IIM), following administration of an anti-CD19 CAR T cell comparable to the FDA-approved tisagenlecleucel. Here, CD19 is linked to systemic lupus erythematosus.