To test the biomedical impact of the putative tethering mechanism of GLUT4, we analyzed two datasets of skeletal muscle tissue biopsied and sequenced directly from patients with critical illness myopathy (CIM) (PRJNA491748) or dermatomyositis (DM) (GSE143323) (Fig. 7a, Supplemental Fig. 10a) 46, 47. Here, SLC2A4 is linked to dermatomyositis.