Intriguingly, even in the face of constitutive GLUT4 trafficking and RLR tethering (Fig. 4l, Fig. 3h, Supplemental Fig. 7b, i, j), 3p-hpRNA and virus infection continued to induce stronger binding between GLUT4 and RLRs in Ubxn9−/− cells (Fig. 5d, e). Here, DHX58 is linked to viral infectious disease.