Idiopathic inflammatory myopathies are autoimmune conditions characterized by muscle inflammation and weakness 48, enriched inflammatory gene signatures, and an upregulation of RIG-I that is now considered a biomarker of DM 49.To first investigate the pertinence of GLUT4 in these autoimmune disorders, we analyzed the pathways enriched in DM patients compared to healthy skeletal muscle using QIAGEN ingenuity pathway analysis (IPA) 46. The gene discussed is RIGI; the disease is autoimmune disease.