GRN and neurodegenerative disease: This perspective is beginning to be adopted by the field with respect to genes implicated in the endolysosomal system including leucine-rich repeat kinase (LRRK2)[93], progranulin (GRN), and glycoprotein non-metastatic B (GPNMB) as risk genes for several neurodegenerative diseases[3, 14, 94].