Starting with dementia associations, we found that variants mapped to LRRC25 were previously reported to be associated with AD-related phenotypes (Table S16), specifically with GWAS of upper vs lower quantiles of AD PRS (rs754032589)56 and a GWAS of AD and gastroesophageal reflux disease (rs3859570; Table S16)57. This evidence concerns the gene LRRC25 and gastroesophageal reflux disease.