In support of the PPI findings, we also found from Agora expression data that the Log2-fold change (L2FC) for LRRC25 (0.47) was nearly identical to that of CR1 (0.36) in AD cases compared to controls in two brain tissues— the inferior frontal gyrus (IFG) and parahippocampal gyrus (PHG), which is not observed novel-known gene pairing in the same tissue (Table S13). This evidence concerns the gene CR1 and Alzheimer disease.