U2AF1 and leukemia: Here, we report the results of our library screening campaign that identified SF1–8 inhibiting U2AF Homology Motifs (UHM) domain of U2AF1 (U2AF1-UHM) required for the binding between U2AF1 and U2AF2 and evaluated the effects of SF1–8 on the viability and molecular pathways in U2AF1S34 mutant leukemia cells.