PICALM has been reported to be an important gene contributing to leukemogenesis and expression pattern change was observed in MDS/AML patients harboring U2AF1 mutation.65 Our analysis of the transcripts of PICALM and VAMP7 showed that isoforms switch in PICALM and VAMP7 led to deletion of NPF and DPF motifs in PICALM that interact with AP2 and a truncated PICALM binding domain in VAMP7. Here, PICALM is linked to acute myeloid leukemia.