found that insulin resistance is positively associated with high LOXL2 expression and the development of fibrosis in patients with T2DM; and consistent with this, the silencing of FoxO1 normalizes LOXL2 expression, thereby ameliorating the fibrosis of InsR+/−(insulin receptor (InsR) haploinsufficiency) MCD(methionine-choline deficient)-fed mice (23). This evidence concerns the gene FOXO1 and type 2 diabetes mellitus.