Thus, a number of miRNAs are associated with diabetic heart failure and cuproptosis, and miR-375 likely interacts with LOXL2 and participates in the development of myocardial fibrosis, while also having an anti-fibrotic effect in combination with miR-27b-3p in exosomes. The gene discussed is LOXL2; the disease is Myocardial fibrosis.