We selected the top 20 genes according to the correlation index and analyzed their expression, finding a significant positive correlation between the expression of BCO2 and TTN and a significant negative correlation between the expression of SNORA80E and TTN. A previous in vitro study showed that mutations or aberrant expression of TTN can cause diabetic cardiomyopathy by truncating the titin protein and causing haploinsufficiency (50). This evidence concerns the gene TTN and diabetic cardiomyopathy.