We selected the top 20 genes according to the correlation index and analyzed their expression, finding a significant positive correlation between the expression of BCO2 and TTN and a significant negative correlation between the expression of SNORA80E and TTN. A previous in vitro study showed that mutations or aberrant expression of TTN can cause diabetic cardiomyopathy by truncating the titin protein and causing haploinsufficiency (50). The gene discussed is BCO2; the disease is diabetic cardiomyopathy.